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- Human Brain During the Early First Trimester (E-Book, PDF)
- The Human Brain During the Early First Trimester
- The Human Brain During the Early First Trimester - CRC Press Book
Presents a unique view of the entire range of structural development Identifies structures previously unknown in humans using H-thymidine autoradiogra It deals with human brain development during the early first trimester from the third through the seventh gestational weeks. Serial sections from 14 specimens are illustrated and annotated in detail, together with 3? D reconstructions of the brains of eight specimens. The Human Brain During the Early First Trimester focuses on these major themes: Growth of the stockbuilding neural progenitor cells along the expanding shorelines of the superventricles Identification of the mosaic It deals with human brain development during the ea The aim of this investigation is threefold: a to determine the time of origin of neurons of the rat cranial nerve ganglia; b to reexamine the embryonic development of the cranial nerve ganglia in the light ofthese dating results; and c to attempt to relate the chronology of these peripheral events to developmental events in those nuclei of the medulla that are intimately associated with the cranial nerve ganglia.
Although thymidine-radiography has been used for over 2 decades to investigate the time of origin of neurons, most of these studies dealt with central nervous struc- tures The aim of this investigation is threefold: a to determine the time of origin of neurons of the rat cranial nerve ganglia; b to reexamine the embr The Development of the Rat Spinal Cord.
The study of the development of the spinal cord has a relatively long history. The spinal cord was singled out as a favorable site when cytological techniques were first applied to the study of the embryonic development of the nervous system. Bidder and Kupffer , using the new procedure of hardening nerve tissue with chromic acid Hannover , made an investigation of spinal cord development in fetal sheep.
They reported that the cellular central mass of the spinal cord develops before its fibrous envelope, deducing from this that the fibers of the white matter of the embryonic The spinal cord was singled out as a favorable site when cytological te The Development of the Rat Hypothalamus. The hypothalamus is a vitally important component of the vertebrate nervous system, being involved in the regulation of the pituitary gland, the autonomic nervous system, and the central and peripheral motor systems; and implicated in such functions as reproduction, feeding, drinking, aggression, vigilance, and some other not clearly understood motivational processes.
Here, we undertook an in silico-based approach to address this question, followed by some functional validation. We found an over-representation of motifs corresponding to binding sites for Pax, Sox, and Lhx transcription factors, often found as pairs and located within bp windows.
Two showed strong enhancer activity in the germinal zone progenitors. Overall, from a cis-regulatory viewpoint, our data suggest an input from Pax, Sox and Lhx transcription factors to orchestrate corticogenesis. These results are discussed with regards to the known functional roles of Pax6, Sox2 and Lhx2 in cortical development. All rights reserved. Wiley Interdiscip Rev Dev Biol. Epub Nov The anatomical tailbud is a defining feature of all embryonic chordates, including vertebrates that do not end up with a morphological tail.
Due to its seamless continuity with trunk tissues, the tailbud is often overlooked as a mere extension of the body axis; however, the formation of the tail from the tailbud undoubtedly involves unique and distinct mechanisms for forming axial tissues, such as the secondary neurulation process that generates the tailbud-derived spinal cord. Tailbud formation in the frog Xenopus laevis has been demonstrated to involve interaction of three posterior regions of the embryo that first come into alignment at the end of gastrulation, and molecular models for tailbud outgrowth and patterning have been proposed.
While classical studies of other vertebrate models, such as the chicken, initially appeared to draw incompatible conclusions, molecular studies have subsequently shown the involvement of at least some similar genetic pathways. Finally, there is an emerging consensus that at least some vertebrate tailbud cells are multipotent progenitors with the ability to form tissues normally derived from different germ layers- a trait normally associated with regeneration of complex appendages, or stem-like cells.
Bending of the neural plate at paired dorsolateral hinge points DLHPs is required for neural tube closure in the spinal region of the mouse embryo. As a step towards understanding the morphogenetic mechanism of DLHP development, we examined variations in neural plate cellular architecture and proliferation during closure.
Neuroepithelial cells within the median hinge point MHP contain nuclei that are mainly basally located and undergo relatively slow proliferation, with a 7h cell cycle length. In contrast, cells in the dorsolateral neuroepithelium, including the DLHP, exhibit nuclei distributed throughout the apico-basal axis and undergo rapid proliferation, with a 4h cell cycle length. As the neural folds elevate, cell numbers increase to a greater extent in the dorsolateral neural plate that contacts the surface ectoderm, compared with the more ventromedial neural plate where cells contact paraxial mesoderm and notochord.
This marked increase in dorsolateral cell number cannot be accounted for solely on the basis of enhanced cell proliferation in this region.
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We hypothesised that neuroepithelial cells may translocate in a ventral-to-dorsal direction as DLHP formation occurs, and this was confirmed by vital cell labelling in cultured embryos. The translocation of cells into the neural fold, together with its more rapid cell proliferation, leads to an increase in cell density dorsolaterally compared with the more ventromedial neural plate.
These findings suggest a model in which DLHP formation may proceed through 'buckling' of the neuroepithelium at a dorso-ventral boundary marked by a change in cell-packing density. Published by Elsevier Inc. The anatomy of the arterial system supplying blood to the brain can influence the development of arterial disease such as aneurysms, dolichoectasia and atherosclerosis. As the arteries supplying blood to the brain develop during embryogenesis, variation in their anatomy may occur and this variation may influence the development of arterial disease.
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Angiogenesis, which occurs mainly by sprouting of parent arteries, is the first stage at which variations can occur. At day 24 of embryological life, the internal carotid artery is the first artery to form and it provides all the blood required by the primitive brain. As the occipital region, brain stem and cerebellum enlarge; the internal carotid supply becomes insufficient, triggering the development of the posterior circulation.
At this stage, the posterior circulation consists of a primitive mesh of arterial networks that originate from projection of penetrators from the distal carotid artery and more proximally from carotid-vertebrobasilar anastomoses. These anastomoses regress when the basilar artery and the vertebral arteries become independent from the internal carotid artery, but their persistence is not uncommon in adults e.
Other common remnants of embryological development include fenestration or duplication most commonly of the basilar artery , hypoplasia typically of the posterior communicating artery or agenesis typically of the anterior communicating artery. Learning more about the hemodynamic consequence that these variants may have on the brain territories they supply may help understand better the underlying physiopathology of cerebral arterial remodeling and stroke in patients with these variants.
During the early steps of head development, ectodermal patterning leads to the emergence of distinct non-neural and neural progenitor cells. The induction of the preplacodal ectoderm and the neural crest depends on well-studied signalling interactions between the non-neural ectoderm fated to become epidermis and the prospective neural plate. By contrast, the involvement of the non-neural ectoderm in the morphogenetic events leading to the development and patterning of the central nervous system has been studied less extensively.
Here, we show that the removal of the rostral non-neural ectoderm abutting the prospective neural plate at late gastrulation stage leads, in mouse and chick embryos, to morphological defects in forebrain and craniofacial tissues. In particular, this ablation compromises the development of the telencephalon without affecting that of the diencephalon.
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Further investigations of ablated mouse embryos established that signalling centres crucial for forebrain regionalization, namely the axial mesendoderm and the anterior neural ridge, form normally. Moreover, changes in cell death or cell proliferation could not explain the specific loss of telencephalic tissue. Finally, we provide evidence that the removal of rostral tissues triggers misregulation of the BMP, WNT and FGF signalling pathways that may affect telencephalon development.
Published by The Company of Biologists Ltd. Syndecan 4 Sdc4 is a cell-surface heparan sulfate proteoglycan HSPG that regulates gastrulation, neural tube closure and directed neural crest migration in Xenopus development. Sdc4 is expressed in multiple tissues, but particularly in the non-neural ectoderm, hindgut and otic vesicles. Sdc4;Vangl2 Lp compound mutant mice have defective spinal neural tube closure, disrupted orientation of the stereocilia bundles in the cochlea and delayed wound healing, demonstrating a strong genetic interaction.
In Xenopus, co-injection of suboptimal amounts of Sdc4 and Vangl2 morpholinos resulted in a significantly greater proportion of embryos with defective neural tube closure than each individual morpholino alone. To probe the mechanism of this interaction, we overexpressed or knocked down Vangl2 function in HEK cells.
The Sdc4 and Vangl2 proteins colocalize, and Vangl2, particularly the Vangl2 Lp mutant form, diminishes Sdc4 protein levels. Conversely, Vangl2 knockdown enhances Sdc4 protein levels. Abstract PURPOSE: The morphological changes and expression patterns of neuronal antigens of human embryos, obtained from the therapeutic termination of pregnancy or from surgical procedures, were analyzed in order to characterize the secondary neurulation. The markers used for immunohistochemical study were neural cell adhesion molecule N-CAM , neuronal nuclear antigen NeuN , neurofilament-associated protein 3A10 , synaptophysin, and glial fibrillary acidic protein GFAP.
The postcloacal gut had completely disappeared at stage 18, and multiple cavities of the caudal neural tube were clearly visible.pewythursverdi.ml
Human Brain During the Early First Trimester (E-Book, PDF)
The caudal portion of the neural tube showed findings suggestive of involution at stage The expression patterns of neuronal antigens were as follows: N-CAM and NeuN showed immunoreactivity at the germinal layer of the spinal cord at stages 17 and Neurofilament-associated protein 3A10 showed persistent immunoreactivity at the caudal cell mass and notochord during the observation period, along with the spinal cord, and the positive reactions were mainly located at the dorsal white matter at stage Synaptophysin showed a weak positive reaction at the caudal cell mass and notochord at stages 13 and 14, evident by staining observed at the spinal cord at stages 15 and There was no definite positive reaction for GFAP.
O'Rahilly R. The longitudinal growth of the neuromeres and the resulting brain in the human embryo. The growth of the human brain during the embryonic period was assessed in terms of longitudinal measurements in staged embryos. Precise graphic reconstructions prepared by the onerous point-plotting method were considered to be the most reliable, and 23 were examined in detail.
The Human Brain During the Early First Trimester
A distinction is necessary between measurements of the brain cerebral diameters and those of the skull osseous diameters , and also between those of the folded brain in situ, studied here, and the later relatively straightened brain. Longitudinal measurements were made of individual neuromeres and their successors in steps neuromeric lengths.
The sum of the neuromeric measurements at any given stage provides the total neuromeric length TNL of the folded brain in situ at that stage and it increases in keeping with the greatest length GL of the embryo. At stages , however, the neuromeric length of the brain may exceed the GL.
The Human Brain During the Early First Trimester - CRC Press Book
From stage 20 onwards the body length increases more rapidly compared with the length of the brain. The most cephalic neuromere is the telencephalon medium, abbreviated T1 here.
The cerebral hemispheres are derived from it, although they are not neuromeres. The hemispheres soon extend rostrally beyond the limit of T1 by an amount that is here designated T2, and that indicates the growth of the telencephalon rostral to the commissural plate, which is the site of the future corpus callosum. Further laterally, the hemispheric length future fronto-occipital diameter increases rapidly, as does also the bitemporal biparietal diameter.
At the end of the embryonic period these diameters are one fourth to one fifth of the head circumference. Additional neuromeric information becomes manifest when the measurements are calculated as percentages of the total length of the brain. The rhombencephalon decreases considerably, diencephalon 2 increases greatly, whereas diencephalon 1 diminishes, and the cerebral hemispheres enlarge massively. In addition, specific neuromeres or subdivisions come to occupy relatively more or relatively less of the total.
Three periods were found during which individual neuromeres acquire their maximal or minimal lengths: the maximal absolute lengths were in period 3, whereas the maximal and minimal percentage lengths were in periods 1 and 3. The various neuromeric changes are considered to be related to alterations in functional development. Finally, in furtherance of establishing continuity in prenatal data, comparisons were effected between embryonic and fetal measurements. Karger AG, Basel. In vertebrates, the development of the nervous system is triggered by signals from a powerful 'organizing' region of the early embryo during gastrulation.
This phenomenon--neural induction--was originally discovered and given conceptual definition by experimental embryologists working with amphibian embryos. This observation is the basis of the 'default' model of neural induction.
In the ventral ectoderm, where the signaling ligands escape the inhibitors, a non-neural fate is induced. Hence the molecular process that delineates neural from non-neural ectoderm is conserved across a broad range of organisms in the evolutionary tree. The availability of embryonic stem cells from mouse, primates, and humans will facilitate further understanding of the role of signaling pathways and their downstream mediators in neural induction in vertebrate embryos.